{"id":83,"count":14,"description":"<p style=\"text-align: center\">The SensiQuant products are designed for the <strong>QUALITATIVE detection<\/strong> and <strong>QUANTITATIVE measurement<\/strong> of <strong>BCR\/ABL<\/strong> transcripts in patients suspected of having Chronic Myeloid Leukemia (CML), Acute Myeloid Leukemia (AML), and Acute Lymphoblastic Leukemia (ALL).<\/p>\n<p style=\"text-align: center\">The product line includes:<\/p>\n\n<ul>\n    <li>SensiQuant <strong>Master Mix<\/strong><\/li>\n    <li>SensiQuant <strong>Standard<\/strong> (from 10^5 to 10 copies)<\/li>\n    <li>SensiQuant <strong>Positive Control<\/strong><\/li>\n    <li><strong>PhilaREF<\/strong> (RNA, from 10% to 0.0032% + Neg)*<\/li>\n    <li><strong>Lyoset Reference<\/strong> (lyophilized cells, from 10% to 0.0032% + Neg)<\/li>\n<\/ul>\n\n<strong>Main Breakpoints in the Cluster<\/strong>\n<ul>\n    <li><strong>\u201cmajor\u201d (M-bcr)<\/strong>, P210 (b2a2\/b3a2) and rare variant b3a3\/b2a3<\/li>\n    <li><strong>\u201cminor\u201d (m-bcr)<\/strong>, P190 (e1a2) and rare variant e1a3<\/li>\n    <li><strong>\u201cmicro\u201d (u-bcr)<\/strong>, P230 e19a2\/e19a3<\/li>\n    <li><strong>\u201cnano\u201d (n-bcr)<\/strong>, e6a2\/e6a3<\/li>\n<\/ul>\n\n<strong>Application<\/strong>\n<ul>\n    <li><u>QUALITATIVE Analysis<\/u> = SensiQuant <strong>Master Mix<\/strong> + SensiQuant <strong>Positive Control<\/strong><\/li>\n    <li><u>QUANTITATIVE Analysis<\/u> = SensiQuant <strong>Master Mix<\/strong> + SensiQuant <strong>Standard<\/strong><\/li>\n<\/ul>\n\n<strong>Reference Materials<\/strong>\n<ul>\n    <li><strong><u>PhilaREF<\/u><\/strong>: RNA reference material for qualitative or quantitative performance assessment of translocation detection assays and, for the P210 transcript, for the calculation of the Conversion Factor (CF)* needed to express final BCR\/ABL P210 quantification data on the International Scale (IS).<\/li>\n    <li><strong><u>Lyoset Reference<\/u><\/strong>: reference material consisting of ampoules with lyophilized mixtures of known quantities of cells positive for the targeted translocation diluted in negative cells. Essential for qualitative or quantitative performance assessment of translocation detection assays.<\/li>\n<\/ul>\n\n<strong>Benefits<\/strong>\n<ul>\n    <li><strong>One-Step Technology<\/strong><\/li>\n    <li><strong>Single plasmid<\/strong> of BCR-ABL and ABL<\/li>\n    <li><strong>Linear Range<\/strong> (1,000,000 to 5 copies BCR-ABL for the most common variants)<\/li>\n    <li><strong>Consistent thermal cycling conditions across different translocations<\/strong> (analyzable in a single run)<\/li>\n    <li><strong>High ABL copy numbers<\/strong> (high sensitivity of the method)<\/li>\n    <li><strong>High specificity, sensitivity, and accuracy<\/strong> (0.00001% of Ph-positive cells in wild-type cells*)<\/li>\n    <li><strong>High reproducibility<\/strong> (intra- and inter-assay)<\/li>\n    <li><strong>Fast and easy to use<\/strong><\/li>\n    <li><strong>High stability<\/strong><\/li>\n    <li><strong>CE\/IVD marking<\/strong> for the most common variants<\/li>\n    <li><strong>LabNet validated<\/strong> (R.I.L. CML LabNet \u2013 Feb2023 \u2013 v 5.0)*<\/li>\n<\/ul>\n\n<strong><em>*<\/em><\/strong><em>Only for kits related to the P210 translocation<\/em>","link":"https:\/\/www.bioclarma.com\/en\/product-category\/oncohematology\/bcr-abl-en\/","name":"BCR-ABL","slug":"bcr-abl-en","taxonomy":"product_cat","parent":81,"meta":[],"menu_order":0,"acf":[],"_links":{"self":[{"href":"https:\/\/www.bioclarma.com\/en\/wp-json\/wp\/v2\/product_cat\/83","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bioclarma.com\/en\/wp-json\/wp\/v2\/product_cat"}],"about":[{"href":"https:\/\/www.bioclarma.com\/en\/wp-json\/wp\/v2\/taxonomies\/product_cat"}],"up":[{"embeddable":true,"href":"https:\/\/www.bioclarma.com\/en\/wp-json\/wp\/v2\/product_cat\/81"}],"wp:post_type":[{"href":"https:\/\/www.bioclarma.com\/en\/wp-json\/wp\/v2\/product?product_cat=83"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}